effects of acute intra-hippocompal injection of bupropion on active avoidance learning in rats
نویسندگان
چکیده
introduction: learning and memory deficits in some diseases are new subjects of research. bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. this study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. methods: adult male wistar rats (obtained from pasteur institute of iran, weighing 200-250 g) were tested for learning behavior in a two-way active avoidance shuttle-box. the animals were divided into control, sham operated, vehicle and 3 treatment groups treated with different doses of intra-hippocampal bupropion (0.25 mg/1 μl, 1.25 mg/5 μl and 2.5 mg/10 μl, injected during 1-2, 5 and 10 min, respectively). drug was injected by a stereotaxic implanted guide cannulae. briefly, 10 days after the stereotaxic surgery, rats were trained (20 trails, 2 times each day) in a twoway active avoidance task shuttle box. sessions were started at the same time of the day and an interval of 5 hours was between the 2 sessions. tests were repeated on 5 consecutive days. rats received bupropion or vehicle 30 min before each test and the learning process was assessed. results: analysis of the data showed significant differences in the number of avoidance reactions in the early sessions of trials of the learning tasks between vehicle and bupropion treated animals (p<0.05). conclusion: bupropion can decrease the number of avoidance reactions and increase the reaction latency. although bupropion is a dopamine reuptake blocker, but it is concluded that bupropion can bind to other receptors such as acetylcholine receptors and interfere with the learning and memory processes. key words: bupropion, shuttle-box, active avoidance learning, hippocampus, antidepressant
منابع مشابه
Effects of acute intra-hippocompal injection of bupropion on active avoidance learning in rats
Introduction: Learning and memory deficits in some diseases are new subjects of research. Bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. This study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. Methods: Adult male ...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولEffect of Intra-CA1 injection of estrogen on spatial memory and learning in rats
Introduction: Sexhormones are one of most important factors in difference of learning and memory between tow sexes (male & female). High concentration of estrogen and androgen receptors and mechanism of testosterone and estrogen production in learning and memory center, especially in hippocampus show the role of this receptors, sexhormons and P450 enzymes in spatial memory. Consequently, in thi...
متن کاملthe effects of integrating cooperative learning into vocabulary learning of elementary school students
the purpose of the research is to examine if integrating cooperative learning into vocabulary learning helps to increase word recognition of students in an elementary school in iran. it tries to investigate whether cooperative learning approach enables students to improve their language learning. this research used stad (students team achievement division) as a cooperative model in this study. ...
15 صفحه اولEffects of intra-fourth ventricle injection of crocin on capsaicin-induced orofacial pain in rats
Objectives: Crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. In the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. The contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. Materials and Methods: A guide cann...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
physiology and pharmacologyجلد ۱۴، شماره ۳، صفحات ۲۹۳-۳۰۱
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023